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Current immunotherapy treatments like pembrolizumab have provided promising results for metastatic colorectal cancer patients who have high microsatellite instability or are mismatch repair deficient. Unfortunately, this consists of only ~5% of the total colorectal cancer sub-population and the majority remain non-responsive to immunotherapy. Based on previously established pre-clinical results, scientists are now exploring combinations of immune-checkpoint inhibitor and MEK inhibitor to target patient populations who...

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Recent support of FDA on avastin biosimilar opens up hope for the cancer patients. Biosimilars are large, structurally complex molecules that are intended to be highly similar to, and treat the same condition(s) as, an existing licensed or approved (reference) biologic, with no clinically meaningful differences in purity, potency and safety. Bevacizumab (Avastin) is a humanized monoclonal antibody that inhibits angiogenesis (the formation of new...

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Age related macular degeneration is the leading cause of people over the age of 50 going blind in western countries. There is 2% chance for a middle aged to catch this disorder and the chance rises to more than 30% in 70s. In addition to having no definite cure for AMD, it is further disheartening that the detection is also slow with AMD patients going...

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Discovery of tumor specific oncogenic biomarkers and molecular tests to identify them are providing treatment options to physicians based on the individual patient’s tumor characteristics. Precision medicines based on these biomarkers are becoming a reality for many diseases including lung cancer. This infographic showcases such interventions which are being developed in NSCLC based on the individual biomarker profile of a patient. Potential therapies based on clinically relevant...

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Lymphocyte Activation Gene 3 (LAG-3) is a cell surface molecule and expressed on activated T cells, natural killer cells, B cells, and plasmacytoid dendritic cells. Dysfunctional T cells can render the immune system unable to eliminate infections and cancer. Therapeutic targeting of the surface receptors that inhibit T cell function has begun to show remarkable success in clinical trials. LAG-3 may be a better checkpoint...

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Calcitonin Gene-Related Peptides (CGRPs) - Major culprit in migraine Migraine is a common neurovascular primary headache disorder with typical clinical features (with an estimated global prevalence of 14.7%). In the Global Burden of Disease Study, updated in 2013, migraine on its own was found to be the sixth highest cause worldwide of years lost due to disability. Activation of trigeminovascular system in the brain that leads...

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